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Using Cryo-Electron Microscopy to Study the 3D Structure of Macromolecules Online

Electron Microscopy utilizes a beam of electrons to form an image of a sample. Electrons, however, have a much shorter wavelength than that of light, and can thus resolve much smaller objects. With the advent of flash freezing samples to preserve their native biological structure -“Cryo-EM” as a technique was born. This enabled the three-dimensional structures of large proteins and viruses to be elucidated but took a quantum leap forward a decade ago with the introduction of direct electron detectors and new automation approaches. Today, Cryo-EM routinely enables the visualization ofthe near-atomic structures of proteins and macromolecular assembles. This lecture will introduce the concepts behind Cryo-EM and give examples of biological structures that have been determined here at Wash U.

Free and open to all, pre-registration required.

Tuesday, February 15, 2022
2:00pm - 4:00pm
Time Zone:
Central Time - US & Canada (change)
This is an online event. Event URL will be sent via registration email.
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Session Presenter

Profile photo of Jennifer Moore
Jennifer Moore